141. Quinolones antibiotics side effects: nausea, stomach upset, headache, drowsiness, dizziness, insomnia, light-headedness and vomiting. Quinolones interactions: excessive caffeine increases nervousness, The absorption of quinolones is reduced by sucralfate, antacids containing aluminum or magnesium and also by calcium, iron, and zinc salts 2hours before or 6 after, quinolones elevate levels of antidiabetic agents that may cause hypoglycaemia, quinolones increases statins levels causing muscle pain, quinolones enhance the effect of Warfarin risk of bleeding.
142. Benzodiazepines side effects: Sedation, confusion, headache, dizziness, fatigue, amnesia, constipation, urinary retention, nausea, weight gain/loss, diplopia, chest pain, nasal congestion, dry mouth and light-headedness.
Benzodiazepines interactions: coffee, tea decrease sedative effect, alcohol increases side effects of BDZs sedation, headache space them 6 hrs, St. John’s wort increases CNS depression.
143. NSAIDs side effects: headache, vertigo, dizziness, nervousness, tinnitus, depression, drowsiness, and insomnia, epigastric pain, nausea, constipation.
NSAIDs interactions: nephrotoxicity may be increased if given with ACEIs, cyclosporine or diuretics, alcohol, warfarin increase the risk of bleeding, decrease antihypertensive effect of antihypertensives, decrease excretion of lithium and aminoglycosides, increase lithium concentration leads to confusion, tremor, polydipsia and polyuria.
144. CCBs side effects: headache, nausea, dizziness, drowsiness, palpitation (dihydropyridine), bradycardia (non-dihydropyridine), peripheral edema (ankle edema), fatigue, flushing, flushing.
CCBs interactions: grapefruit juice and ketoconazle increase levels of CCBs, alcohol with CCBs may cause hypotension and increase side effects space between them by 6 hrs, NSAIDs decrease antihypertensive effect of CCBs, St. John’s wort decreases levels of CCBs, beta-blockers increase risk of bradycardia with NHP-CCBs.
145. SSRIs side effects: nausea, headache, drowsiness, dizziness, constipation, diarrhoea, weakness, insomnia, dry mouth, sexual dysfunction, Anorexia and weight loss, weight gain. SSRIs interactions: alcohol increases side effects of SSRIs, valerian, St. John’s wort increase side effects of SSRIs, ASA increase the risk of bleeding.
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