Pharma Tips-324

1636. Clarithromycin may cause QT prolongation if taken with ketoconazole.

1637. Low-dose ASA decreases the secretion of uric acid, hence increasing gouty attacks.

1638. Nicotinic acid competes with the uric acid excretion in the kidneys, increasing uric acid levels and increasing the risk of a gout attack.

1639. Cytotoxic drugs increase nucleic acids due to cell lysis, leading to an increase in uric acid, increasing gout attacks.

1640. Minimum inhibitory concentration (MIC) indicates the lowest concentration of an antibiotic that prevents microbial growth after 18-24 hours of incubation.

Pharma Tips-323

1631. Reason for non-compliance:

• Asymptomatic conditions.
• Chronic conditions.
• Cognitive impairment, especially forgetfulness.
• Complex regimens.
• Multiple daily doses. 
• Patient's fear of side effects.
• Poor communication between patients and practitioners.
• Psychiatric illness.

1632. Meperidine may increase the incidence of seizures.

1633. Bismuth subsalicylate is used for traveller's diarrhoea, may cause constipation, black tongue and stool.

1634. Carbamazepine may cause ataxia and diplopia. 

1635. Sucralfate, aluminium and magnesium antacids decrease the absorption of ciprofloxacin.