216. Plasma albumin is the major protein for binding of various drugs, it mostly binds to acidic drugs, basic drugs tend to bind to beta-globulin and acid-glycoprotein.
217. Cataplexy is a sudden and transient episode of loss of muscle tone, often triggered by emotions, often associated with people who have narcolepsy and treated with TCAs like imipramine, clomipramine or venlafaxine or sodium oxybate if with narcolepsy.
218. Hemochromatosis is pathology in which iron accumulates in the tissues; characterized by bronzed skin and enlarged liver and diabetes mellitus and abnormalities of the pancreas and the joints.
219. Antacids neutralize existing gastric acid secreted by the parietal cells and increase the pH of the stomach and duodenal bulb. Antacids also inhibit the conversion of pepsinogen to pepsin by increasing pH. Antacids do not inhibit gastric acid secretion.
220. P. aeruginosa is the most common bacterial pathogen isolated from the sputum of cystic fibrosis patients followed by S. aureus and H. influenzae.
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