31. Phenoxybenzamine forms an irreversible covalent bond with acetylcholine receptors.
32. Adenylate cyclase forms cyclic-AMP from ATP.
33. Atropine will prevent you from sweating and then becoming very hot, and that is called Atropine flushing.
34. Parasympathetic receptors in the eye sphincter have M3 receptors, which cause miosis (contraction), and ciliary muscles have M3 receptors to help with accommodation for near vision.
35. The heart has M2 receptors in the SA node that decrease the heart rate (-ve inotorpy), and in the AV node, M2 receptors decrease the conduction velocity (chronotropic).
36. Lungs have M3 receptors that cause contraction (bronchospasm). M3 receptors are found in the glands and increase the secretions.
37. Stomach has M3 receptors when activate them cause cramps and increase motility, M1 receptors present in glands of the stomach and increase secretions of acid, M3 receptors present in GIT and increase motility causing diarrhoea.
38. The bladder has M3 receptors that cause contraction of the body and relaxation of the sphincter.
39. Blood vessels have M3 receptors, causing dilation by the release of nitric oxide; they are not innervated.
40. Pilocarpine is a cholinomimetic used in open-angle glaucoma and in xerostomia.
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