21. Type ІІ statistical error the data shows no difference between two treatment regimens and a difference actually does exist.
22. Lithium is an ion but can cross BBB because it has a very small molecular weight, also ethanol, lithium is toxic to fetus.
23. Phase І reaction like oxidation, reduction or hydrolysis, phase ІІ reaction is the conjugation reactions.
24. Ethanol acts as CYP450 3A4 inhibitor when it is used acutely, but chronically it acts as an inducer.
25. You cannot induce P450 2D6, but you can inhibit it.
26. There are some people who are fast hydroxylators so they eliminate drugs faster than others do and they need higher doses example codeine.
27. Morphine when conjugates it will form an active compound.
28. Neonates do not have transferases enzymes that responsible on conjugation.
29. Glutathione conjugation for metabolism of acetaminophen.
30. Morphine and meperidine (pethidine) is full agonist, codeine is partial agonist that may act as antagonist in the presence of full agonist.
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