Pharma Tips-119

616. Succinylcholine is a skeletal muscle relaxant, it is used as adjunctive to anesthetics in some surgical procedures, it causes fasciculation (muscle twisting) after anesthesia.
617. Haloperidol is an inhibitor of CYP2D6.
618. Monoamine-oxidase enzyme metabolizes dopamine (DA), norepinephrine (NE), 5-HT, and tyramine.
619. Alcohol dehydrogenase metabolizes alcohol to an aldehyde which is metabolized by acetaldehyde dehydrogenase, aldehyde metabolism is inhibited by disulfiram leading to accumulation of aldehyde, causing many effects like hangover and flushing (redness of face), disulfiram-like reaction.
620. Morphine is metabolized to an active metabolite by glucuronidation. Acetalyation is done for INH, procainamide, hydralazine. Sulfation is done for minoxidil, steroids. Glutathione conjugation is done for acetaminophen.

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