311. The half-life of drugs is variable in zero-order kinetics, and constant in first-order kinetics, in zero-order a constant amount is being eliminated.
312. LD (loading dose)= Vd (volume of distribution) × Css (steady state concentration).
313. Maintenance dose (MD) = clearance (CL) * Css * (dose interval).
314. Steady state concentration (Css) means the rate of drug enter the body is equal to the rate of drug exits the body.
315. Rate in = amount / time, rate out = volume/ time, Css= rate in /rate out (clearance).
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