246. Phenytoin should not be administered intravenously, due to venous irritation and cardiac adverse effects.
247. Carbamazepine is an enzyme inducer, it induces its own metabolism, dose adjustment is needed when it is used with phenytoin within 2-4 weeks of being added or discontinued.
248. Barbiturates suppress the signal transmission across the synapses and thereby raise the seizure threshold.
249. Lantus insulin should not be mixed with any other insulin.
250. It takes 10-21 days for optimal response to lithium therapy.
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