Pharma Tips-55

296. No DNA replication means no myelosuppression that’s why drugs are only affecting newly formed cells, because they are dividing so fast.
297. CL (total body clearance) = K × Vd (volume of distribution).
298. Vd = total amount of drug/ Initial plasma concentration (C◦).
299. Insulin receptors belong to tyrosine kinase family.
300. Sulfonamides + dihydrofolate reductase inhibitors such as trimethoprim, and penicillins + aminoglycosides are the best examples of synergy.

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