Pharma Tips-359

1811. Amiodarone is used to treat ventricular fibrillation and ventricular tachycardia and may cause pulmonary fibrosis; it has a very long half-life of about 50 days.
1812. Norepinephrine is the drug of choice in the treatment of septic shock for adults.
1813. Anticoagulants: warfarin is active only in vivo; LMWH is active in vivo and minimally active in vitro; and heparin is active in vivo and in vitro. 
1814. Cyclophosphamide may cause severe hemorrhagic cystitis and pulmonary fibrosis; patients should drink plenty of fluids before and after doses.
1815. Bactrim may cause megaloblastic anemia due to folic acid deficiency and may cause hemolytic anemia in patients with G6PD. 

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