376. Wheat bran is the best choice to promote regular bowel movement.
377. Hypertension treatment: uncomplicated hypertension; 1st-line, thiazide (HCT); 2nd-line, combos of 1st line; isolated systolic hypertension (ISH); 1st-line, thiazide, calcium channel blockers (CCBs) the dihydropyridine type, angiotensin receptor blockers. 2nd-line, ACEIs+ CCBs> ACEIs+ HCT. Hypertension + diabetes (nephropathy); 1st-line, ACEIs or ARBs. 2nd-line, addition of thiazide, HCT<25mg. Hypertension+diabetes(no nephropathy); 1st-line, ACEIs or ARBs or thiazide or DHP-CCBs. 2nd-line, 1st-line+ cardiodelective beta-blocker or non-DHP-CCB. Hypertension (ISH) with diabetes and no nephropathy; 1st-line, ACEIs or ARBs or thiazide or CCBs- DHP. Hypertension + coronary artery disease; 1st-line, ACEIs or ARBs. 2nd-line, CCB-DHP. Hypertension+ angina; 1st-line, beta-blocker ±ACEIs or CCBs. 2nd-line, ARBs or ( hydralazine+ isosorbide dinitrate), amlodipine, or felodipine, thiazide/loop diuretic as additive. Hypertension + TIA; ACEIs + diuretic (perindopril + indapamide). Hypertension + prior to MI; 1st-line, beta-blocker (BB) + ACEIs or ARBs. 2nd-line, CCBs. Hypertension + heart failure; 1st-line, ACEIs or ARBs + BBs ( bisoprolol, carvedilol, metoprolol) ± diuretic ( spironolactone). Hypertension + renal diseaese and proteinuria; 1st-line, ACEIs + diuretics as a dditive therapy. 2nd-line, ACEIs + ARBs. Hypertension + left ventricular hypertrophy (LVH); ACEIs, ARBs, CCBs-LA, diuretics, BBs.
378. Dyslipidemia and peripheral arterial disease (PAD) does not affect the initial treatment of hypertension.
379. Avoid the use of hydralazine and minoxidil incase of left-ventricular hypertrophy (LVH).
380. Incase of PAD avoid using BBs, and CCBs would be a useful approach.
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