1601. Toxicity may occur for a drug that is highly albumin-bound (more free drug in the blood) for the following cases:
- Hypoalbuminemia.
- Hepatic disease.
- Malnutrition.
- Cancer diseases cause albuminemia (decreased albumin levels). So doses must be monitored.
1603. LABAs increase the risk of asthma-related deaths (they must be used with inhaled corticosteroids for uncontrolled asthma and should not be used alone), and they are not used for acute asthma.
1604. Myocardial infarction is the leading cause of heart failure in people aged 40-50 years old.
1605. Corticosteroids may cause heart failure ( sodium and water retention).
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