1091. Metoclopramide increases the absorption of levodopa by enhancing gastric emptying.
1092. Sinemet treatment after several years may cause akinesia (inability to initiate movement), tremor, and rigidity; this is called the on-off effect of the sinemet.
1093. Drug holiday must be given in the treatment of sinemet to prevent down-regulation of dopamine receptors.
1094. Selegiline dose when exceeds 40mg/day will result in loss of MAO-B selectivity.
1095. Bromocriptine (Parlodel) has the longest duration of action among all Parkinson's drugs (~50hrs half-life).
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