321. Overstimulation of receptors may cause desensitization, which means receptors, will not respond anymore.
322. Physostigmine is tertiary amine crosses the blood brain barrier, so it is used in atropine toxicity.
323. Pralidoxime (2- PAM) regenerates acetylcholine esterase (AchE) within 2 hours of toxicity with organophosphates (malathion).
324. Amiodarone and bleomycin both can cause pulmonary fibrosis.
325. Tricyclic antidepressants, potassium channel blockers, and antipsychotics cause torsades reaction.
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