Pharma Tips-215

1096. Bromocriptine long treatment may produce pleural infusion, thickening, and pulmonary infiltrates.

1097. Haloperidol has the lowest sedation and the highest Extrapyramidal side effects (EPS) among all antipsychotics.

1098. Neuroleptic malignant syndrome (NMS) is associated with haloperidol, depot fluphenazine, chlorpromazine, trifluoperazine, and prochlorperazine.

1099. Penicillinase-resistant penicillins such as; methicillin, nafcillin, oxacillin, and dicloxacillin.

1100. Otitis media can be treated with augmentin (amoxicillin + clavulanate).

Pharma Tips-214

1091. Metoclopramide increases the absorption of levodopa by enhancing gastric emptying.

1092. Sinemet treatment after several years may cause akinesia (inability to initiate movement), tremor, and rigidity; this is called the on-off effect of the sinemet.

1093. Drug holiday must be given in the treatment of sinemet to prevent down-regulation of dopamine receptors.

1094. Selegiline dose when exceeds 40mg/day will result in loss of MAO-B selectivity.

1095. Bromocriptine (Parlodel) has the longest duration of action among all Parkinson's drugs (~50hrs half-life).