Pharma Tips-246

1251. Verapamil and diltiazem have negative inotropic effects.

1252. For low cardiac output may use milrinone or dobutamine.

1253. Thiazide diuretics may be used in mild heart failure.

1254. Loop diuretics may be used in decompensated heart failure. 

1255. Ethacrynic acid is used as an alternative to loop diuretics (allergy) and has more ototoxicity.

Pharma Tips-245

1246. Heart failure symptoms may include fatigue, dyspnea, and fluid retention.

1247. Doxorubicin, cocaine, cyclophosphamide, imatinib, trastuzumab, and alcohol are cardiotoxic drugs.

1248. Sodium intake in heart failure is less than 2-3 g/day and 1-2 g/day in severe heart failure. 

1249. Eplerenone (aldosterone antagonist) does not cause gynecomastia.

1250. Nitrates + hydralazine combination is used in heart failure.