Pharma Tips-229

1166. Interferons cause flu-like symptoms.

1167. The best trial clinical study for a new drug is randomized control trials.

1168. The normal pH of the vagina is 4.5-5, but during menstruation, the pH increases.

1169. Signs are things that appear to our eyes, and symptoms are things that are told by patients.

1170. Topical corticosteroids and anti-inflammatory agents are the mainstays of treatment of aphthous ulcers (triamcinolone, betamethasone. clobetasol paste).

Pharma Tips-228

1161. Varenicline treatment should be started 1-2 weeks prior to the date of stopping smoking, and continue for 12 weeks and another 12 weeks after successful quitting.

1162. Metyrapone is used in the diagnosis of adrenal insufficiency and in the treatment of Cushing's syndrome.

1163. Sodium docusate is the best and the safest laxative for elderly patients. 

1164. All aerosols and inhalers need priming except Imitrex (sumatriptan).

1165. Biliary colic prevents the absorption of vitamin K.

Pharma Tips-227

1156. Raloxifene decreases the absorption of levothyroxine, they need to be separated by several hours (12hrs).

1157. Rasagiline is MAOI used alone or adjunct to levodopa to treat Parkinson's disease.

1158. Allow 14 days after stopping rasagiline before taking antidepressants, st. John's wort, dextromethorphan, pseudoephedrine, or meperidine to prevent a hypertensive crisis.

1159. Simvastatin may increase the effect of anticoagulants and decrease the effect of clopidogrel.

1160. Acetazolamide when taken with topiramate may increase the risk of kidney stones. 

Pharma Tips-226

1151. Antibiotics, MAOIs, and oral antidiabetic drugs increase the risk of low blood sugar if given with insulin.

1152. Lactulose may reduce the release of mesalazine at the site of action.

1153. Magnesium hydroxide (milk of magnesia) is used as an antacid, it may cause diarrhea, so it is usually given in a combination with the aluminum hydroxide to counteract its laxative effect.

1154. Take folinic acid if you are taking methotrexate to prevent the destruction of the bone marrow and wash your hands after handling methotrexate tablets.

1155. Posaconazole is an antifungal drug used to treat aspergillosis and other fungal infections resistant to other fungal treatments, its bioavailability increases to 90% if taken with high-fat meals. 

Pharma Tips-225

1146. After stopping MAOIs you can start taking fluoxetine after 2 weeks.

1147. After stopping fluoxetine you can start taking MAOIs after 5 weeks.

1148. Fluticasone nasal spray should be started 2-3 weeks before the hayfever season to treat allergic rhinitis.

1149. Formoterol is not recommended in children under 6 years of age.

1150. Ibuprofen may increase the levels of digoxin, lithium, and methotrexate.

Pharma Tips-224

1141. Nitrate patches should be removed before sleep to avoid tolerance.

1142. Loop diuretics are vasodilators by the effect on prostaglandins.

1143. At the start of allopurinol treatment, the drug may cause an acute attack of gout.

1144. Bupropion is used for smoking cessation for up to 9 weeks, it is recommended to be stopped if no progress is made.

1145. Antihistamines should be discontinued approximately 2-3 days before an allergy skin test.