Pharma Tips-203

1036. Aminoglycosides nephrotoxicity and ototoxicity are increased with vancomycin, amphotericin B, cisplatin, and cyclosporine.

1037. Fluoroquinolones, metronidazole, sulfonamides increase warfarin action by increasing INR.

1038. Triazole antifungals like fluconazole are hepatotoxic.

1039. Probenecid decreases renal clearance of antivirals drugs like acyclovir.

1040. Opioids, digoxin, antibiotics may cause nausea and vomiting.

Pharma Tips-202

1031. Linezolid may cause serotonin syndrome with MAOIs or SSRIs. 

1032. Caspofungin is used to treat candidemia in patients with or without neutropenia.

1033. Itraconazole is only available in oral formulation and is used to treat aspergillosis.

1034. Posaconazole is used for refractory invasive fungal infections.

1035. Sulfamethoxazole/trimethoprim are used for prophylaxis against pneumocystis jirovecii and inhaled pentamidine and dapsone are used as alternatives.

Pharma Tips-201

1026. Atacand (candesartan) is a prodrug to increase the bioavailability of the drug.

1027. Ceftazidime is a drug of choice of pseudomonas aeruginosa cause of meningitis.

1028. Imipenem can cause seizures with theophylline.

1029. Carbapenems decrease valproic acid levels.

1030. Ciprofloxacin increases INR with warfarin, and causes nephrotoxicity with cyclosporine.

Pharma Tips-200

1021. Folic acid is given during pregnancy to prevent neural tube defects.

1022. Common conditions that are associated with edema CHF, cirrhosis, renal failure, nephrotic syndrome and pregnancy. 

1023. Drugs that may cause edema NSAIDs, calcium channel blockers (CCBs), corticosteroids (CTS), or drugs that interact with diuretics. 

1024. Ethacrynic acid is a diuretic and used in sulfa-allergic patients; may cause severe ototoxicity. 

1025. Tacrolimus and cyclosporine increase potassium levels.   

Pharma Tips-199

1016. Sulfasalazine decreases the GI absorption of digoxin.

1017. Drugs associated with fractures like proton pump inhibitors (PPIs), SSRIs, and high doses of vitamin A.

1018. Calcitonin causes non-severe epistaxis, sinusitis, nausea, vomiting and rhinitis.

1019. Cyclobenzaprine and orphenadrine are muscle relaxants.

1020. Isotretinoin causes depression and suicidal thoughts.