Pharma Tips-188

961. To lessen the pain, intramuscular injection of Penicillin into a larger gluteal muscle should be administered over 12 to 15 seconds to separate the muscle fibres more gradually.

962. Ketoconazole absorption increases by food which stimulates secretion of gastric enzymes increasing the gastric acid environment.

963. Sunscreen or sunblock applications may not prevent sunburn in clients receiving ciprofloxacin, so a patient should limit the exposure to the sun too.

964. To minimize the metallic or bitter taste of metronidazole; it should be taken with food except for Flagyl ER, which should be taken 1 hour before or 2 hours after meals.

965. "Red man syndrome" or "red neck syndrome" is the flushing of the face, neck, and upper chest associated with too rapid IV administration of vancomycin.

Pharma Tips-187

956.Tetracycline is absorbed best when given on an empty stomach with a glass of water. Food, dairy products, iron, and antacids decrease the absorption of this drug.

957.  NPH insulin is used to lower blood sugar level in diabetes; the drug's effect peaks over 4 to 12 hours and lasts 24 hours.

958. Vitamin K antagonizes Coumadin's effects; any food (such as broccoli or cabbage) or drugs that contain vitamin K decreases the effects of the drug.

959. Administration of vitamin B6 is recommended during therapy with isoniazid (INH) to reduce the incidence of peripheral neuritis, which may be associated with isoniazid.

960. Rifampin causes an orange-red discolouration of body fluids including urine, tears, sweat.

Pharma Tips-186

951. The treatment with alteplase should be initiated within 3 hours after the onset of stroke symptoms and after exclusion of intracranial haemorrhage by CT scan or any other diagnostic image method sensitive for the presence of haemorrhage.

952. Topotecan is a topoisomerase inhibitor and it can cause anaemia, neutropenia, thrombocytopenia.

953. Non-selective beta-blocking agents should be avoided in patients with diabetes type-I & asthma.

954. Heparin can be given by subcutaneous injection, intravenous infusion, or intermittent IV injection.

955. Insulin glargine (Lantus) is long-acting insulin with onsets around 1.5 hours, no peak, and duration of 20-24 hours.