Pharma Tips-184

941.  Protamine sulfate is the antidote for heparin overdosage.

942. Hydrolysis of penicillin G is rapid in the GIT.

943. Mineral oil acts only by lubricating the intestinal tract. It has very mild or secondary properties of fecal softening.

944. A humectant such as glycerin helps to retain moisture and prevent drying due to evaporation.

945. Vitamins A, D, E, and K are fat soluble.

Pharma Tips-183

936. Trough concentrations are indicative of drug accumulation. To decrease only the trough level and maintain peak concentrations, lengthening the dosing interval is the method of choice.

937. Vitamin K is necessary for the formation of prothrombin.

938. Due to its high pH, sodium bicarbonate is incompatible with many common IV medications.

939. Cellulose acetate phthalate is used as enteric coating material.

940. The most widely used method for sterilization of pharmaceuticals is moist heat.