Pharma Tips-258

1311. Drugs that might cause pancreatitis are alcohol, metronidazole, azathioprine, pentamidine, cimetidine, ranitidine, sulfonamides, estrogens, tetracycline, furosemide, thiazides, valproate, glucocorticoids, and mercaptopurine.
1312. Drugs that might cause photosensitivity reactions are amiodarone, naproxen, amitriptyline, oral contraceptives, doxepin, oral hypoglycemics, fluoxetine, phenothiazines, piroxicam, furosemide, griseofulvin, sulfonamide, isotretinoin, tetracycline, ketoprofen, nalidixic acid, and thiazides.
1313. Drugs that might cause parkinsonism are butyrophenones like haldol, heavy metal poisoning, phenothiazines like thorazine, and reserpine. 
1314. Drugs that might induce or cause hyperglycemia are amiodarone, nicotinic acid, oral contraceptives, epinephrine, pentamidine, phenytoin, estrogens, glucocorticoids, thyroid hormones, and lithium. 
1315. Drugs that should be avoided in pregnancy are atorvastatin, methotrexate, benzodiazepines, misoprostol, ergotamine, pravastatin, finasteride, raloxifene, fluorouracil, simvastatin, fluoroquinolones, tetracyclines, fluvastatin, thalidomide, vitamin A, isotretinoin, warfarin, and lovastatin. 

Pharma Tips-257

1306. Sweat test is used for cystic fibrosis diagnosis.
1307. Drugs that might cause liver failure are acetaminophen, niacin, niacin, ketoconazole, allopurinol, methotrexate, carbamazepine, cytarabine, erythromycin, flucytosine, gancyclovir, sulfonylureas, valproate, INH, nitrofurantoin, and oral control medications.
1308. Drugs that might affect renal function are NSAIDs, aminoglycosides, gold salts, foscarnet, amphotericin B, cisplatin, cyclosporine, pentamidine, and ACEIs.
1309. Drugs that may cause folic acid deficiency are barbiturates, primidone, methotrexate, oral contraceptives, phenytoin, sulfasalazine, trimethoprim, and triamterene.  
1310. Drugs that might cause erythematosus-like reactions are ethosuximide, phenothiazine, hydralazine, isoniazid, methyldopa, procainamide, quinidine, nitrofurantoin, sulfonamides, penicillamine, and tetracycline.

Pharma Tips-256

1301. Warfarin toxicity antidote is vitamin K.
1302. Coombs test is antibody screening for blood/donor/recipient compatibility.
1303. Prostate-specific antigen test is used for screening to detect prostate cancer.
1304. Prothrombin time is used to monitor warfarin therapy. 
1305. Reinsch test is used to detect heavy metals in biological samples. 

Pharma Tips-255

1296. Heparin toxicity antidote is protamine sulfate.
1297. Iron toxicity antidote is deferoxamine.
1298. Methotrexate toxicity antidote is leucovorin.
1299. Morphine (opiate) toxicity antidote is naloxone.
1300. Organophosphate toxicity antidotes are pralidoxime, atropine and Benzodiazepines.

Pharma Tips-254

1291. Vitamin D deficiency causes rickets.
1292. Acetaminophen toxicity antidote is N-acetylcysteine.
1293. Benzodiazepine toxicity antidote is flumazenil.
1294. Digoxin toxicity antidote is digoxin immune fab. 
1295. Dopamine toxicity antidote is phentolamine.  

Pharma Tips-253

1286. Vitamin C deficiency causes scurvy.
1287. Vitamin B12 deficiency causes pernicious anaemia.
1288. Folic acid deficiency causes megaloblastic anemia.
1289. Niacin deficiency causes pellagra.
1290. Thiamine B1 deficiency causes beriberi, wernicke-korsakoff syndrome.

Pharma Tips-252

1281. Oppositional defiant disorder occurs in 35% of children with ADHD.
1282. Dextroamphetamine side effects may include insomnia, decreased appetite, and headache. 
1283. CNS stimulants block dopamine and norepinephrine receptors. 
1284. Nifedipine can be used in Raynaud's s syndrome treatment. 
1285. Nifedipine side effects may include flush, tachycardia, headache, orthostatic hypotension, & oedema. 

Pharma Tip-251

1276. Beta-blockers decrease the risk of myocardial infarction and they are not recommended for older than 60 years.
1277. Pentoxifylline is a xanthine derivative; that decreases blood viscosity, and may cause nausea, and flushing, it reduces the adenosine effect and increases the effect of theophylline, warfarin, antihypertensive and hypoglycemic drugs.
1278. Cilostazol inhibits platelet aggregation, due to the inhibition of phosphodiesterase type 3. 
1279. ADHD predominant inattentive requires 6 out of 9 symptoms, also mostly hyperactive/impulsive requires 6 out of 9 symptoms, combined inattentive and hyperactive/impulsive require 12 out of 18 symptoms. 
1280. Atypical antipsychotics are helpful in both ADHD and Tourettes syndrome.

Pharma Tips-250

1271. Procainamide may induce systemic lupus erythematosus. 
1272. Octreotide + midodrine used in post-prandial hypotension.
1273. Raloxifene increases the risk of venous thromboembolism.
1274. Warfarin may be used safely with breastfeeding women.
1275. Angiotensin-converting enzyme inhibitors (ACE) decrease the risk of ischemic events.


Pharma Tip-249

1266. Heparin reduces the risk of deep vein thrombosis but increases the risk of intra- and extra-cranial bleeding.
1267. After "Administration of alteplase 24 hours no aspirin or clopidogrel etc. 
1268. Flecainide or propafenone are not used in structural heart disease.
1269. Verapamil may cause constipation, hypotension, flushing, and bradycardia. 
1270. Magnesium is used for torsades de pointes.

Pharma Tip-248

1261. Antiplatelet drugs are the drugs of choice for long-term prevention of atherothrombotic events.
1262. Ticlopidine may cause diarrhea, skin rash, and neutropenia.
1263. Oral contraceptives increase the risk of ischemic stroke.
1264. Warfarin is contra-indicated in pregnancy.
1265. Alteplase should be given within 3 hours of a stroke. 

Pharma Tips-247

1256. Hydralazine may cause lupus like syndrome.
1257. Drug interaction between nitrates and sildenafil may lead to severe hypotension.
1258. Digoxin and verapamil increase the rick of bradycardia.
1259. Non-modifiable risk factor include age, sex, and family history. 
1260. Modifiable risk factors include blood pressure, dyslipidemia, smoking, and diabetes.  

Pharma Tips-246

1251. Verapamil and diltiazem have negative inotropic effects.
1252. For low cardiac output may use milrinone or dobutamine.
1253. Thiazide diuretics may be used in mild heart failure.
1254. Loop diuretics may be used in decompensated heart failure. 
1255. Ethacrynic acid is used as an alternative to loop diuretics (allergy) and has more ototoxicity.

Pharma Tips-245

1246. Heart failure symptoms may include fatigue, dyspnea, and fluid retention.
1247. Doxorubicin, cocaine, cyclophosphamide, imatinib, trastuzumab, and alcohol are cardiotoxic drugs.
1248. Sodium intake in heart failure is less than 2-3 g/day and 1-2 g/day in severe heart failure. 
1249. Eplerenone (aldosterone antagonist) does not cause gynecomastia.
1250. Nitrates + hydralazine combination is used in heart failure.